Multisystem chronic conditions are disorders in which multiple body systems—such as the nervous, vascular, digestive, musculoskeletal, and immune systems—are affected simultaneously. Symptoms can range widely, from dizziness and pain to digestive issues and persistent fatigue.
Folate, or vitamin B9, plays a vital role in the functioning of the body. It is essential for the synthesis of DNA and RNA, regulates methylation, and supports normal cell growth and development. A deficiency of folate in the brain can lead to serious consequences, including cognitive and neurological disorders.
Upon consumption, folates are absorbed in the intestine and transported to various organs via the folate receptor alpha (FRα). Under normal conditions, the folate level in cerebrospinal fluid (CSF) should be 2-3 times higher than in blood. However, in some individuals, blood folate levels may remain within the normal range while the delivery of folate to the brain is inadequate.
Methylation is a crucial biochemical process occurring in all cells of the body. It involves adding a methyl group (CH₃) to molecules such as DNA, proteins, and lipids, significantly influencing their functions and activities. Methylation regulates various physiological mechanisms, including gene expression, detoxification, mood regulation, energy production, immune system function, and cellular maintenance. Particularly important is the role of methylation in the liver, where it helps neutralize and eliminate toxins, which is essential for overall health.
Depression is a serious mental disorder characterized by a prolonged period of low mood, loss of interest in favorite activities, changes in energy balance, and a decreased sense of satisfaction with life. It affects overall physical and emotional well-being, the ability to function in daily life, and the quality of interpersonal relationships.
Depression can have different degrees of severity, and without timely treatment, it can become chronic and negatively impact the quality of life. However, depression can also be a symptom of other medical or psychological conditions. Distinguishing between depression as a symptom and depression as a standalone condition is usually based on the duration, frequency, severity of symptoms, and their impact on daily life.
In recent years, issues related to gluten-free diets have been gaining increasing attention. Some people encounter problems associated with its consumption, undergo tests, identify celiac disease, and eliminate gluten from their diets. Meanwhile, for others, the celiac test comes back negative, and gluten remains an integral part of their diet. But are they right? Let’s delve into this topic; in this article, we will explore various issues related to gluten. You’ve got it right; it’s not just about celiac disease.
In the first part of the article, we discussed information useful for those who want to know more about lupus and suspect this issue in themselves or their loved ones.
