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Actinomycetes are a group of Gram-positive bacteria that occupy an intermediate position between bacteria and fungi. They form branched filamentous structures resembling mold mycelium and are capable of producing spores. While many species of actinomycetes are found in nature and play a role in the decomposition of organic matter, some strains can be pathogenic and pose a health risk when they begin to proliferate in the indoor environment.

Microbiome refers to the collection of microorganisms that inhabit not only the gut, but also the skin, respiratory tract, mucous membranes, urogenital system, and even the surrounding environment. The human body contains more microbial cells than human cells: for every human cell, there are about 1.3 microbial cells. The total mass of the microbiome is 1.5–2 kg, and its genes outnumber human genes by a factor of 150.

Food colorings are additives used to give, enhance, or restore the color of food and beverages. They can be either synthetic (artificial) or natural, derived from plants, minerals, or animals.

Manufacturers use colorings to make products more appealing, as bright colors are associated with freshness and quality. They also help compensate for the loss of natural color that occurs during processing, freezing, and storage. Additionally, certain shades create a recognizable image for the product — for example, oranges are dyed to match consumer expectations.

Traveling is a wonderful opportunity to gain new life experiences, but it can also pose health risks. When in enclosed spaces such as airplanes, or in crowded places like airports, travelers are more likely to encounter infections that spread from person to person.

The events of recent years, associated with the coronavirus pandemic, have shown how quickly diseases can spread around the world. But viruses are only part of the problem. During travel, one may also encounter bacterial infections, which can be just as dangerous. That’s why it is important not only to understand how infections are transmitted, but also to know how to protect yourself.

For effective treatment of dysbiosis, it is crucial to begin with accurate diagnostics. In the first article, we discussed the basic concepts of dysbiosis, its impact on health, and potential causes. Many health conditions may present with similar symptoms but require different treatment approaches. As mentioned earlier, dysbiosis-related issues can be identified using a variety of diagnostic methods. The primary ones are stool analysis and breath tests. Stool analysis can detect the presence of pathogenic bacteria, viruses, and fungi, while breath tests effectively reveal carbohydrate fermentation disorders, which may indicate SIBO (small intestinal bacterial overgrowth).

Gut Microbiota is a complex ecosystem of microorganisms, including bacteria, viruses, fungi, and parasites, that inhabit the human intestinal tract. The number of microbes in the human body is estimated to be around 39 trillion, slightly exceeding the number of human cells. However, their genetic material is much richer and has a profound impact on bodily functions.

The microbiota performs many key functions, such as aiding digestion, synthesizing vitamins, protecting against pathogens, and supporting the immune system. A healthy microbiota is key to maintaining long-term health, whereas imbalances may trigger a wide range of diseases.

The second part of the article focuses on the diagnosis of Small Intestinal Bacterial Overgrowth (SIBO), continuing the discussion of essential topics not covered in Part One. In that part, we reviewed the core symptoms and causes of SIBO. Now we focus on diagnostic tools that help identify this condition and guide optimal therapy. Distinguishing between the different types of SIBO — hydrogen, methane, and hydrogen sulfide — requires accurate diagnostic methods to select the correct treatment. Importantly, diagnosing SIBO not only confirms the condition but helps rule out other diseases with similar symptoms.

SIBO (Small Intestinal Bacterial Overgrowth) is a condition where bacteria that are normally present in small amounts in the small intestine—or that typically reside in the large intestine—begin to proliferate in the small intestine. SIBO disrupts normal digestion and nutrient absorption.

Symptoms of SIBO include bloating, abdominal pain, diarrhea, or constipation. However, it’s not just discomfort—SIBO can significantly impact quality of life, leading to chronic fatigue, skin issues, weight loss, and vitamin and mineral deficiencies. The underlying cause of SIBO is often another condition, and SIBO is a dysfunction of the gut that results from this primary issue.

Mycoplasmas are unique bacteria characterized by the absence of a cell wall. Instead, they have a cytoplasmic membrane, which makes them distinct from microorganisms. This feature complicates their detection by the immune system and renders antibiotics targeting the cell wall ineffective.

However, drugs such as tetracyclines and macrolides, which act on other mechanisms like protein synthesis, remain effective against these microorganisms. Mycoplasmas can cause many diseases, including respiratory tract infections, urogenital infections, and chronic inflammatory conditions.

Epstein-Barr Virus (EBV) is a type 4 herpesvirus and one of eight known viruses in the Herpesviridae family. It is primarily transmitted through saliva and other bodily fluids, earning it the nickname &“kissing virus”.

EBV can affect various organs and systems in the body. For instance, it may influence the central nervous system (linked to multiple sclerosis) and the thyroid gland (as seen in Hashimoto’s thyroiditis). Additionally, EBV is associated with certain types of cancer, such as nasopharyngeal carcinoma, Burkitt lymphoma, and Hodgkin’s lymphoma.