Multisystem chronic conditions are disorders in which multiple body systems—such as the nervous, vascular, digestive, musculoskeletal, and immune systems—are affected simultaneously. Symptoms can range widely, from dizziness and pain to digestive issues and persistent fatigue.
Folate, or vitamin B9, plays a vital role in the functioning of the body. It is essential for the synthesis of DNA and RNA, regulates methylation, and supports normal cell growth and development. A deficiency of folate in the brain can lead to serious consequences, including cognitive and neurological disorders.
Upon consumption, folates are absorbed in the intestine and transported to various organs via the folate receptor alpha (FRα). Under normal conditions, the folate level in cerebrospinal fluid (CSF) should be 2-3 times higher than in blood. However, in some individuals, blood folate levels may remain within the normal range while the delivery of folate to the brain is inadequate.
