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Ozone Therapy as a Promising Treatment for Chronic Diseases

Ozone is an active form of oxygen that contains three atoms of oxygen, rather than the two atoms we typically breathe. The clinical use of ozone depends on the concentration and volume applied.

Areas of application for ozone:

There are three popular areas of application for ozone in alternative medicine:

  • Ozone has strong antimicrobial effects against bacteria, viruses, and fungi.
  • Ozone improves blood circulation and has been used for both external and internal use.
  • The immune system is highly responsive to ozone therapy and various ozone concentrations. Ozone can stimulate, reduce, or suppress the body’s protective mechanisms.

Effects of ozone on the body:

Ozone therapy is beneficial for various diseases due to its regenerative effects, as it:

  • Activates and improves the immune system’s function in infectious diseases, enhancing the activity of leukocytes. Our body naturally produces ozone, so when it receives additional ozone directly into tissues or the bloodstream, it aids the immune system.
  • Modulates the immune system function for individuals with autoimmune diseases, helping prevent it from attacking healthy human cells.
  • Modulates and reduces inflammation. Studies have shown that ozone therapy effectively reduces inflammatory cytokines in the body and stimulates the body’s natural anti-inflammatory response. Reducing and eliminating inflammation is an important step in treating any disease process.
  • Improves cellular oxygen utilization, reducing oxygen deficiency in cardiovascular diseases and other conditions related to poor tissue oxygenation.
  • Enhances mitochondrial function. Mitochondria are cellular organelles responsible for energy production. Ozone helps them recover and produce more energy, often resulting in reduced fat.
  • Stimulates the release of growth factors that promote the regeneration of damaged joints and degenerative discs.
  • Can reduce chronic pain by affecting pain receptors and improving tissue oxygenation.
  • Helps eliminate heavy metals and non-metal toxic substances from the body by altering their charge and thereby expelling them from the blood, cells, and nervous tissues.
  • Improves blood quality. It makes red blood cells flow with less viscosity and become more flexible to pass through narrowed or obstructed arteries. This occurs through changes in the iron charge present in red blood cells. It improves blood circulation, cellular metabolism, reduces cholesterol and uric acid levels in the body.
  • Reduces body acidification, acts as an antioxidant, and slows down aging processes in the body.
  • Acts as a natural antiviral, antibacterial, antifungal, and antiparasitic agent. When ozone comes into contact with these organisms, they rupture and die. Additionally, microorganisms cannot develop resistance to ozone, unlike antibiotics and other medications.

Its therapeutic effects have been demonstrated in interstitial cystitis, chronic hepatitis, herpes infections, dental infections, diabetes, and macular degeneration, as supported by published research.

What is Autohemotherapy?

Autohemotherapy is the process of taking a person’s blood, cleansing it, and reintroducing it back into the same patient’s body. Much more common in Europe than in the United States and Canada, autohemotherapy can improve the condition of many diseases. In North America, it is considered alternative treatment, but it is well-studied and supported by numerous European studies.

Reintroducing your own blood into muscles, tissues, or veins prompts your immune system to re-recognize any metabolic byproducts (heavy metals, chemical overload, infectious agents) and restart the immune reaction to them. Similar to how we think of treating allergies by introducing a small amount of toxins, autohemotherapy works on the immune system, showing it what toxic and infectious problems are present in the body.

Autochemotherapy Overview of Popular Therapies

Overview of Popular Autohemotherapy Treatments:

  • Minor Autohemotherapy (MiAH): The practicing physician takes a minimal amount of blood, mixes it with ozone, and reintroduces it into the patient’s gluteal muscle. Ozone provides cells and tissues with oxygen and eliminates pathogens. This method is known to have a profound impact on acne, allergies, various skin conditions, and chronic neurological disorders.
  • Major Autohemotherapy (MAH): Multiple syringes of blood are drawn, mixed with ozone, and reintroduced intravenously over a period of 45-60 minutes. This therapy option is known to improve the condition of macular degeneration, rheumatoid arthritis, gout, Lyme disease, and malignant tumors.
  • Neurotherapy in combination with tissue ozone injections: Improvement of colloidal formations and systemic effects on the body.
  • Bagging and cupping: Topical treatment of limbs for poorly healing ulcers, diabetic ulcers. The ozone concentration gradually increases or decreases after each procedure.
  • Nasal/oral/ear/rectal/vaginal infusions: Can be performed more frequently than other procedures (except for bags). These are the most accessible forms of ozone therapy that can be self-administered at home. To do this, you need to pick up an ozone packet at the office and transport it home in a cooler bag. The concentration and volume of ozone gradually increase depending on individual characteristics and conditions. Infusions can be combined with other ozone therapies for greater effect.
  • Ozonated oils: Ozonated oils do not contain ozone; they contain ozonides. Their application can be beneficial for many conditions, including joint disorders, dermatitis, eczema, acne, infected hair follicles, fungal nail infections, and psoriasis.

Who Can Benefit from Ozone Therapy?

Here is a list of diseases and conditions where ozone therapy can be used as additional or adjunctive treatment:

  • Musculoskeletal Disorders: Rheumatoid arthritis, osteoarthritis, tendinitis, bursitis.
  • Cardiovascular Diseases: Ischemic heart disease, hypertension, cerebrovascular diseases, peripheral vascular diseases.
  • Respiratory Diseases: Bronchial asthma, chronic obstructive pulmonary disease (COPD).
  • Immune Disorders: Autoimmune diseases (e.g., systemic lupus erythematosus, Crohn’s disease), multiple sclerosis, Autism.
  • Gastrointestinal and Digestive Disorders: Crohn’s disease, ulcerative colitis, peptic ulcers, gastritis.
  • Neurological Disorders: Parkinson’s disease, degenerative neurological disorders.
  • Eye Diseases: Glaucoma, cataracts, diabetic retinopathy.
  • Skin Conditions: Psoriasis, atopic dermatitis, ulcers, and burns.
  • Infectious Diseases: Chronic viral infections (e.g., herpes, HIV), bacterial infections (Lyme disease).
  • Overall Health Enhancement and Antioxidant Support: Strengthening the immune system, improving circulation, increasing energy and endurance.
  • Metabolic and Endocrine Disorders: Diabetes, obesity, hypothyroidism.
  • Genitourinary Disorders: Prostatitis, gynecological conditions, infertility.
  • Systemic Inflammatory Conditions: Vasculitis, chronic inflammatory syndrome.
  • Wounds and Injuries: Burns, complex wounds, traumatic injuries.
  • Mitochondrial Disorders: Conditions associated with mitochondrial deficiency.
  • Aging and Lifespan Extension: Enhancing the quality of life during aging.
  • Cancer: Some studies explore ozone therapy as an adjunct therapy in cancer management because ozone therapy suggests may help induce apoptosis (programmed cell death) in cancer cells.

Ozone therapy can be beneficial for many conditions and has very few contraindications. To determine if this therapy is suitable for you, it is necessary to consult a doctor who has experience in its use and knows which conditions respond best to specific ozone usage methods. The doctor will also check for any contraindications to this therapy.


Hernández F, Menéndez S, Wong R. Decrease of blood cholesterol and stimulation of antioxidative response in cardiopathy patients treated with endovenous ozone therapy. Free Radic Biol Med. 1995 Jul;19(1):115-9. doi: 10.1016/0891-5849(94)00201-t.[PMID: 7635353] [DOI: 10.1016/0891-5849(94)00201-t]